Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Read More
8
We explored how specific gene-nutrient interactions affect high blood pressure using data from the Korean Genome and Epidemiology Study, which included over 50,000 participants.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Read More
Most Useful Reviews
9
Supports cardiovascular health
Great Doctor's Best Active B Complex includes all eight essential B vitamins, which are vital for cellular metabolism and overall health. Quatrefolic®, the most bioavailable form of folate, aids in supporting DNA, cardiovascular disease health, and mental well-being. This complex promotes energy production and helps maintain DNA, contributing to body metabolism and overall wellness.
Read More
7.5
Emotional support
16 people found this helpful
Helping the nervous system. This excellent complex contains the B vitamins in suitable dosages and forms. My husband and I took them during a stressful three-month period, alongside inositol and magnesium. Eventually, our emotional state improved, enabling us to make informed decisions. We concluded that we should regularly use this for stress management to avoid psychosomatic consequences of cardiovascular disease.
Read More
9
Supports metabolism
4 people found this helpful
Excellent! This complex contains 5-methyltetrahydrofolate, the bioavailable form of folate that supports DNA and proper cell division. Methylcobalamin, the active form of vitamin B12, aids cardiovascular health and boosts my energy while reducing fatigue. The dosages in one capsule are very good!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
8
We explored how specific gene-nutrient interactions affect high blood pressure using data from the Korean Genome and Epidemiology Study, which included over 50,000 participants.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Read More
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Read More
8
We looked into how dietary niacin might affect mortality rates, particularly for cardiovascular disease. Analyzing data from nearly 27,000 U.S. adults over about nine years, we found that those with the highest niacin intake had a significantly lower risk of dying from any cause, as well as from heart-related issues.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Read More
7
We investigated the connection between blood pressure variability (BPV) and vitamin B6 and B12 levels in individuals with essential hypertension. Our study involved 100 patients with hypertension and a control group of 100 healthy individuals.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports cardiovascular health
Great Doctor's Best Active B Complex includes all eight essential B vitamins, which are vital for cellular metabolism and overall health. Quatrefolic®, the most bioavailable form of folate, aids in supporting DNA, cardiovascular disease health, and mental well-being. This complex promotes energy production and helps maintain DNA, contributing to body metabolism and overall wellness.
Read More
7.5
Emotional support
16 people found this helpful
Helping the nervous system. This excellent complex contains the B vitamins in suitable dosages and forms. My husband and I took them during a stressful three-month period, alongside inositol and magnesium. Eventually, our emotional state improved, enabling us to make informed decisions. We concluded that we should regularly use this for stress management to avoid psychosomatic consequences of cardiovascular disease.
Read More
9
Supports metabolism
4 people found this helpful
Excellent! This complex contains 5-methyltetrahydrofolate, the bioavailable form of folate that supports DNA and proper cell division. Methylcobalamin, the active form of vitamin B12, aids cardiovascular health and boosts my energy while reducing fatigue. The dosages in one capsule are very good!
Read More
7.5
Increased ferritin
2 people found this helpful
A wonderful complex! Due to gastrointestinal issues, I often need proton pump inhibitors, leading to B vitamin deficiencies and anaemia. This high-quality complex has helped raise my haemoglobin and ferritin levels when combined with the drug Totema. Note that your urine may turn bright yellow, but don't worry. I highly recommend this supplement.
Read More
7.5
Improved energy
Working B-complex. The product quality is good, and the capsules are medium-sized and easy to swallow. The neutral taste and standard packaging for 60 capsules allows for a two-month course. I regularly take this B-complex, as it aids my cardiovascular system, boosts my energy levels, and improves my metabolism.
Read More
Frequently Asked Questions
7.5
Improved energy
Working B-complex. The product quality is good, and the capsules are medium-sized and easy to swallow. The neutral taste and standard packaging for 60 capsules allows for a two-month course. I regularly take this B-complex, as it aids my cardiovascular system, boosts my energy levels, and improves my metabolism.
7.5
Emotional support
16 people found this helpful
Helping the nervous system. This excellent complex contains the B vitamins in suitable dosages and forms. My husband and I took them during a stressful three-month period, alongside inositol and magnesium. Eventually, our emotional state improved, enabling us to make informed decisions. We concluded that we should regularly use this for stress management to avoid psychosomatic consequences of cardiovascular disease.
9
Supports metabolism
4 people found this helpful
Excellent! This complex contains 5-methyltetrahydrofolate, the bioavailable form of folate that supports DNA and proper cell division. Methylcobalamin, the active form of vitamin B12, aids cardiovascular health and boosts my energy while reducing fatigue. The dosages in one capsule are very good!
7.5
Increased ferritin
2 people found this helpful
A wonderful complex! Due to gastrointestinal issues, I often need proton pump inhibitors, leading to B vitamin deficiencies and anaemia. This high-quality complex has helped raise my haemoglobin and ferritin levels when combined with the drug Totema. Note that your urine may turn bright yellow, but don't worry. I highly recommend this supplement.
5
Homocysteine reduction
I often take this complex as prescribed by my doctor. It successfully reduces homocysteine levels while supporting my cardiovascular system.
7.5
Enhanced well-being
One of the best vitamin B complexes. The vitamins play several roles in the body, mainly affecting the brain, nervous system, and cardiovascular disease. Vitamin B12 is critical for DNA production, while vitamins B6 and B1 support heart health. Folic acid and B6 help with emotional stability, improving overall well-being.
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
8
We explored how specific gene-nutrient interactions affect high blood pressure using data from the Korean Genome and Epidemiology Study, which included over 50,000 participants.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
8
We looked into how dietary niacin might affect mortality rates, particularly for cardiovascular disease. Analyzing data from nearly 27,000 U.S. adults over about nine years, we found that those with the highest niacin intake had a significantly lower risk of dying from any cause, as well as from heart-related issues.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
References
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. doi:10.26402/jpp.2025.1.02
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Song Y, Choi JE, Park JM, Kwon YJ, Hong KW, et al. Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES). Nutrients. 2024;16. doi:10.3390/nu16234147
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. doi:10.1016/j.clnesp.2024.11.034
- Lin L, Chen S, Zhang C, Li L, Chen Y, et al. Association of dietary niacin intake with all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2018. Sci Rep. 2024;14:28313. doi:10.1038/s41598-024-79986-9
